Empowering Healthcare and life sciences with
advanced lab-on-chip technology...
Our services built upon past innovations
At Point-of-Care Microfluidics Pvt. Ltd., we develop FET-based biosensors integrated PDMS Lab-on-Chip (LOC) devices for ionic and biochemical sensing in medical diagnostics, food safety, and pharmaceuticals. Our nanoelectrode array biosensors enable ultra-sensitive, multiplexed detection for biosensing and quantum computing. We also design microfluidic reactors for colloidal and nanoparticle synthesis, ensuring precise reaction control and scalability. Additionally, we fabricate sub-100 nm nanofluidic channels with gold nanoelectrodes, advancing applications in DNA sequencing, drug delivery, and energy storage, driving next-generation point-of-care and nanofluidic technologies.
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Electrochemical biosensors
Field-effect transistor (FET)-based biosensors have garnered significant attention for ionic and biochemical sensing applications across medical diagnostics, environmental monitoring, food safety, and pharmaceutical research. We have developed a highly integrated, mm²-scale polydimethylsiloxane (PDMS)-based Lab-on-Chip (LOC) device, combining electronics with nanotransistor biosensors on SOI platform. This innovation is driving a transformation in medical technology, offering an affordable, compact blood diagnostic system. Our prototype successfully measures sodium, potassium, calcium, and magnesium concentrations in blood serum without ion-selective membranes, enabling precise, on-chip detection for cost-effective point-of-care diagnostics and treatment.
Ref: R. Sivakumarasamy, R. Hartkamp, B. Siboulet, J.-F. Dufreche, K. Nishiguchi, A. Fujiwara, and N. Clément, Selective layer-free blood serum Ionogram based on ion-specific interactions with a Nanotransistor, Nature Materials 17, pages 464–470 (2018).
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Nanoelectrode array biosensors
Nanoelectrode array biosensors offer high sensitivity and selectivity, enabling the detection of ultra-low biomarker concentrations with exceptional accuracy. Their multiplexed detection capability allows simultaneous analysis of multiple analytes, making them highly efficient for comprehensive diagnostics. With an enhanced signal-to-noise ratio, they minimize background interference, ensuring precise measurements. Additionally, their rapid and miniaturized design supports portable, real-time monitoring, making them ideal for point-of-care applications.
We have successfully fabricated sub-10nm gold nanodot arrays on silicon substrates using Electron Beam Lithography (EBL). This cutting-edge technique can be extended to fabricate various metal nanoparticles on silicon and quartz substrates, enabling nanoelectronics, plasmonics, biosensing, and quantum computing.
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Microfluidic reactor for colloidal material & nanoparticle synthesis
At POINT-OF CARE MICROFLUIDICS Pvt. Ltd. with our in-house lab facility we can successfully fabricate microfluidic reactor in a miniaturized platform designed for the controlled synthesis of colloidal materials, offering precise reaction conditions, enhanced uniformity, and scalability. By leveraging microfluidic channels, these reactors enable rapid mixing, efficient heat/mass transfer, and precise reagent control, leading to the production of monodisperse nanoparticles, quantum dots, and other colloidal materials.
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Nanofluidics
Nanofluidics is the study and manipulation of fluids confined within nanoscale channels (typically <100 nm). At this scale, fluid behavior deviates from classical hydrodynamics due to enhanced surface interactions, electrokinetic effects, and molecular confinement, leading to unique transport properties. Nanofluidics plays a crucial role in various fields, particularly in biosensing and diagnostics, where it enables DNA sequencing, single-molecule analysis, and biomarker detection with high precision. It is integral to lab-on-chip systems, facilitating miniaturized platforms for chemical and biological assays. In energy and environmental science, nanofluidics enhances water filtration, ion transport, and the development of nanofluidic batteries, contributing to sustainable energy solutions. Its ability to control fluids at the nanoscale makes it a powerful tool for next-generation technological advancements.
In our in-house lab, we have successfully fabricated nanofluidic channels below 100 nm using top-down electron beam lithography (EBL). Additionally, we have achieved precise selective placement of gold nanoelectrodes (sub-10 nm) within the channels and advanced 3D nanofluidic structures, enabling enhanced control over nanoscale fluid transport.
Ref: S. Punniyakoti, R. Sivakumarasamy, F. Vaurette, P. Joseph, K. Nishiguchi, A. Fujiwara, N. Clément, Hydrogen Silsesquioxane- Based Nanofluidics, Advanced Material Interfaces, 2017, 4, 1601155.